Protein as a possible explanation for skin cell renewal

Published: Monday, Nov 18th 2024, 12:00

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Researchers at the University of Geneva have discovered an important mechanism in the renewal of skin cells. For the first time, the protein interleukin-38 was observed in the form of condensate in the cells of the epidermis.

This protein is a messenger substance that is involved in the regulation of inflammatory reactions, as the University of Geneva announced on Monday. The epidermis is the top layer of skin that protects the body from external attacks. It relies on stem cells in the lower skin layer for its renewal. The new cells are pushed from the bottom to the top, where they die.

This process is called keratinization and describes a protective barrier of dead cells. Although the renewal of the epidermis is well documented, there is still a lack of precise understanding of the mechanisms behind it, according to the researchers.

Based on the discoveries made, the Geneva researchers now suspect that the increased oxygen concentration on the surface of the skin promotes the formation of protein condensate, such as that of interleukin-38. The skin cells absorb this condensate and thus know that the time has come for them to die. These findings can also help to better understand certain skin diseases.

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